BAIT
MUS7
mms22, SPAC6B12.02c
DNA repair protein Mus7/Mms22
GO Process (4)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
PREY
RAD51
rhp51, SPAC644.14c
RecA family recombinase Rad51/Rhp51
GO Process (9)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.
The faithful replication of the genome, coupled with the accurate repair of DNA damage, is essential for the maintenance of chromosomal integrity. The MMS22 gene of Saccharomyces cerevisiae plays an important but poorly understood role in preservation of genome integrity. Here we describe a novel gene in Schizosaccharomyces pombe that we propose is a highly diverged ortholog of MMS22. Fission ... [more]
Genetics Sep. 01, 2007; 177(1);47-61 [Pubmed: 17660542]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID