BAIT
DIS3
rrp44, SPBC26H8.10
3'-5' exoribonuclease subunit Dis3
GO Process (12)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- mitotic sister chromatid segregation [IMP]
- ncRNA catabolic process [ISO]
- nonfunctional rRNA decay [ISO]
- nuclear polyadenylation-dependent mRNA catabolic process [ISO]
- nuclear polyadenylation-dependent rRNA catabolic process [ISO]
- nuclear polyadenylation-dependent tRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [ISO]
- nuclear-transcribed mRNA catabolic process, non-stop decay [ISO]
- positive regulation of Ran GTPase activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SWI6
SPAC824.10c, SPAC664.01c
HP1 family chromodomain protein Swi6
GO Process (12)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin remodeling [NAS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromosome passenger complex localization to kinetochore [NAS]
- donor selection [IMP]
- gene conversion at mating-type locus [IMP]
- mating type switching [IMP]
- mitotic sister chromatid cohesion [IGI]
- negative regulation of reciprocal meiotic recombination [IMP]
- protein localization to chromosome, centromeric region [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function.
BACKGROUND: Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in chromosome segregation during mitosis is only poorly understood. The Dis3 ribonuclease is a key component of the RNA-processing exosome complex. Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces pombe suggested that Dis3 is also required for correct ... [more]
PLoS ONE Mar. 24, 2007; 2(3);e317 [Pubmed: 17380189]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID