BAIT
SPC7
SPCC1020.02
kinetochore protein blinkin, Spc7
GO Process (6)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- Bub1-Bub3 complex localization to kinetochore [IMP]
- attachment of mitotic spindle microtubules to kinetochore [IGI, IMP]
- cellular protein localization [IMP]
- cellular response to pheromone [IMP]
- mitotic sister chromatid segregation [IMP]
- signal transduction involved in mitotic spindle assembly checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIS6
SPAC1687.20c
inner centromere protein, CENP-I ortholog Mis6
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.
Spc7, a member of the conserved Spc105/KNL-1 family of kinetochore proteins, was identified as an interaction partner of the EB1 homologue Mal3. Spc7 associates with the central centromere region of the chromosome but does not affect transcriptional silencing. Here, we show that Spc7 is required for the integrity of the spindle as well as for targeting of MIND but not ... [more]
Mol. Biol. Cell Jul. 01, 2007; 18(7);2441-54 [Pubmed: 17442892]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID