BAIT
NCOR1
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
nuclear receptor corepressor 1
GO Process (14)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of JNK cascade [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, TAS]
- regulation of fatty acid transport [IC]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NR1D2
BD73, EAR-1R, RVR
nuclear receptor subfamily 1, group D, member 2
GO Process (12)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- gene expression [TAS]
- intracellular receptor signaling pathway [TAS]
- lipid homeostasis [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of circadian rhythm [ISS]
- regulation of energy homeostasis [ISS]
- regulation of inflammatory response [ISS]
- regulation of lipid metabolic process [ISS]
- regulation of skeletal muscle cell differentiation [ISS]
- regulation of transcription, DNA-templated [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA, TAS]
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.
Rev-erbA alpha and RVR/Rev-erb beta/BD73 are orphan steroid receptors that have no known ligands in the 'classical sense'. These 'orphans' do not activate transcription, but function as dominant transcriptional silencers. The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) act as transcriptional silencers by binding corepressors (e.g. N-CoR/RIP13 and SMRT/TRAC-2) in the absence of ligands. The molecular basis ... [more]
Nucleic Acids Res. Nov. 15, 1996; 24(22);4379-86 [Pubmed: 8948627]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR1D2 NCOR1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID