BAIT

MAL2

SPAC25B8.14
kinetochore protein, CENP-O ortholog Mal2
Schizosaccharomyces pombe (972h)
PREY

NDA2

SPBC16A3.15c
tubulin alpha 1
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast mal2+ is required for chromosome segregation.

Fleig U, Sen-Gupta M, Hegemann JH

By a screen designed to isolate new fission yeast genes required for chromosome segregation, we have identified mal2+. The conditionally lethal mal2-1 allele gives rise to increased loss of a nonessential minichromosome at the permissive temperature and leads to severe missegregation of the chromosomes at the nonpermissive temperature. Cloning by complementation and subsequent sequence analysis revealed that mal2 is a ... [more]

Mol. Cell. Biol. Nov. 01, 1996; 16(11);6169-77 [Pubmed: 8887647]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID