BAIT
CD14
CD14 molecule
GO Process (17)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- apoptotic process [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA]
- cellular response to lipoteichoic acid [IDA]
- innate immune response [TAS]
- phagocytosis [TAS]
- positive regulation of tumor necrosis factor production [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LBP
BPIFD2
lipopolysaccharide binding protein
GO Process (22)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- acute-phase response [IEP, ISS]
- cellular defense response [ISS]
- cellular response to lipopolysaccharide [IDA]
- cellular response to lipoteichoic acid [IDA]
- defense response to Gram-negative bacterium [IDA, ISS]
- defense response to Gram-positive bacterium [IDA]
- detection of molecule of bacterial origin [IDA]
- innate immune response [IC, ISS, TAS]
- lipopolysaccharide transport [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage activation involved in immune response [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- opsonization [IC, ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage activation [IDA]
- positive regulation of respiratory burst involved in inflammatory response [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of tumor necrosis factor production [IDA, ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response.
The kinetics of the interaction of lipopolysaccharide (LPS), lipopolysaccharide binding protein (LBP) and CD14 was studied using surface plasmon resonance. The association and dissociation rate constants for the binding of LPS and rsCD14 were 2.9 x 10(4) M(-1) s(-1) and 0.07 s(-1) respectively, yielding a binding constant of 4.2 x 10(5) M(-1). Significantly, the presence of LBP increased not only ... [more]
FEBS Lett. Nov. 06, 2002; 531(2);184-8 [Pubmed: 12417309]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD14 LBP | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID