An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.

Publication

Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.

Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y

We have isolated a novel cell-cell adhesion system localized at cadherin-based adherens junctions (AJs). This system consists of at least nectin, a Ca(2+)-independent immunoglobulin-like adhesion molecule, and afadin, an actin filament-binding protein, that connects nectin to the actin cytoskeleton. Nectin constitutes a family consisting of two members, nectin-1 and -2. We have isolated here a third member of the nectin ... [more]

J. Biol. Chem. Apr. 07, 2000; 275(14);10291-9 [Pubmed: 10744716]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PVRL3

Gene Ontology Biological Process

Gene Ontology Molecular Function

cell adhesion molecule binding [IPI]protein binding [IPI]protein homodimerization activity [ISS]

Gene Ontology Cellular Component