MAP2K7
Gene Ontology Biological Process
- JNK cascade [ISO]
- activation of JUN kinase activity [IDA, ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to UV [ISO]
- response to heat [ISO]
- response to osmotic stress [ISO]
- response to stress [IDA]
- response to tumor necrosis factor [ISO]
- stress-activated MAPK cascade [IDA, ISO]
Gene Ontology Molecular Function
MAPK8IP3
Gene Ontology Biological Process
- JNK cascade [IDA]
- activation of JUN kinase activity [IDA]
- axon guidance [IMP]
- forebrain development [IMP]
- in utero embryonic development [IMP]
- lung alveolus development [IMP]
- lung morphogenesis [IMP]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of neuron differentiation [ISO]
- positive regulation of signal transduction [IPI]
- post-embryonic development [IMP]
- protein localization [IMP]
- regulation of JNK cascade [IDA]
- regulation of gene expression [IDA]
- respiratory gaseous exchange [IMP]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.
The c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) is activated in response to the treatment of cells with inflammatory cytokines and by exposure to environmental stress. JNK activation is mediated by a protein kinase cascade composed of a MAPK kinase and a MAPK kinase kinase. Here we describe the molecular cloning of a putative molecular scaffold protein, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP2K7 MAPK8IP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID