MYOG
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- mRNA transcription from RNA polymerase II promoter [TAS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of muscle atrophy [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of skeletal muscle fiber development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- regulation of myoblast fusion [ISS]
- regulation of satellite cell proliferation [ISS]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to electrical stimulus involved in regulation of muscle adaptation [ISS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- skeletal muscle tissue development [TAS]
- striated muscle atrophy [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
POLR2C
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- DNA repair [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA splicing, via spliceosome [TAS]
- nucleotide-excision repair [TAS]
- positive regulation of viral transcription [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin.
RNA polymerase II core subunit 3 (RPB3) is an a-like core subunit of RNA polymerase II (pol II). It is selectively down-regulated upon treatment with doxorubicin (dox). Due to the failure of skeletal muscle cells to differentiate when exposed to dox, we hypothesized that RPB3 is involved in muscle differentiation. To this end, we have isolated human muscle RPB3-interacting proteins ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POLR2C MYOG | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| POLR2C MYOG | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| POLR2C MYOG | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID