BAIT

NOS1AP

6330408P19Rik, CAPON
nitric oxide synthase 1 (neuronal) adaptor protein
Alzheimer's Disease Project
GO Process (3)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

SYN1

SYN1a, SYN1b, SYNI, RP1-230G1.2
synapsin I
GO Process (3)
GO Function (4)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.

Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH

The specificity of the reactions of nitric oxide (NO) with its neuronal targets is determined in part by the precise localizations of neuronal NO synthase (nNOS) within the cell. The targeting of nNOS is mediated by adapter proteins that interact with its PDZ domain. Here, we show that the nNOS adapter protein, CAPON, interacts with synapsins I, II, and III ... [more]

Proc. Natl. Acad. Sci. U.S.A. Mar. 05, 2002; 99(5);3199-204 [Pubmed: 11867766]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SYN1 NOS1AP
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-

Curated By

  • BioGRID