AVEN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APAF1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [IDA, TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- nervous system development [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- response to G1 DNA damage checkpoint signaling [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.
Bcl-x(L), an antiapoptotic Bcl-2 family member, is postulated to function at multiple stages in the cell death pathway. The possibility that Bcl-x(L) inhibits cell death at a late (postmitochondrial) step in the death pathway is supported by this report of a novel apoptosis inhibitor, Aven, which binds to both Bcl-x(L) and the caspase regulator, Apaf-1. Identified in a yeast two-hybrid ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID