BAIT
TRIM37
MUL, POB1, TEF3
tripartite motif containing 37
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- aggresome assembly [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of centriole replication [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein autoubiquitination [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
H2AFY
H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
H2A histone family, member Y
GO Process (11)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dosage compensation [IDA]
- establishment of protein localization to chromatin [IMP]
- negative regulation of cell cycle G2/M phase transition [IMP]
- negative regulation of gene expression, epigenetic [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI, IMP]
- nucleosome assembly [NAS]
- regulation of cell growth [IGI]
- regulation of chromatin silencing at rDNA [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3?-?-Catenin Signaling Pathway.
The tripartite motif-containing family member TRIM37 is involved in a number of important biological and pathological processes, and it has recently been shown to be an essential regulator of protein ubiquitination and a contributor to tumorigenesis. We previously showed that TRIM37 is overexpressed in and promotes the proliferation and invasion of pancreatic cancer (PC).Sphere formation, flow cytometric, qRT-PCR, western blot, ... [more]
Front Oncol Nov. 17, 2020; 10();554787 [Pubmed: 33194618]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
Curated By
- BioGRID