BAIT
MEF2C
C5DELq14.3, DEL5q14.3
myocyte enhancer factor 2C
GO Process (98)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- MAPK cascade [IDA, IMP]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cardiac ventricle formation [ISS]
- cell morphogenesis involved in neuron differentiation [ISS]
- cellular response to calcium ion [ISS]
- cellular response to drug [ISS]
- cellular response to fluid shear stress [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to parathyroid hormone stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to trichostatin A [ISS]
- chondrocyte differentiation [ISS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in renal tubule morphogenesis [ISS]
- germinal center formation [ISS]
- glomerulus morphogenesis [ISS]
- heart development [IEP, ISS, NAS]
- heart looping [ISS]
- humoral immune response [ISS]
- innate immune response [TAS]
- learning or memory [ISS]
- melanocyte differentiation [ISS]
- muscle cell differentiation [TAS]
- muscle cell fate determination [ISS]
- muscle organ development [TAS]
- myotube differentiation [IEP]
- negative regulation of gene expression [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of ossification [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nephron tubule epithelial cell differentiation [ISS]
- nervous system development [TAS]
- neural crest cell differentiation [ISS]
- neuron development [ISS]
- neuron differentiation [IEP, ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoblast differentiation [ISS]
- outflow tract morphogenesis [ISS]
- platelet formation [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of behavioral fear response [ISS]
- positive regulation of bone mineralization [ISS]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of neuron differentiation [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of protein homodimerization activity [ISS]
- positive regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of skeletal muscle tissue development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- primary heart field specification [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of dendritic spine development [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of germinal center formation [ISS]
- regulation of megakaryocyte differentiation [ISS]
- regulation of neuron apoptotic process [ISS]
- regulation of neurotransmitter secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic activity [ISS]
- regulation of synaptic plasticity [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of transcription, DNA-templated [IDA]
- renal tubule morphogenesis [ISS]
- response to ischemia [ISS]
- response to virus [IEP]
- secondary heart field specification [ISS]
- sinoatrial valve morphogenesis [ISS]
- skeletal muscle tissue development [ISS]
- smooth muscle cell differentiation [ISS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [IDA, ISS]
- ventricular cardiac muscle cell differentiation [ISS]
Gene Ontology Molecular Function- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
- AT DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- miRNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
MYOG
MYF4, bHLHc3, myf-4
myogenin (myogenic factor 4)
GO Process (19)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- mRNA transcription from RNA polymerase II promoter [TAS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of muscle atrophy [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of skeletal muscle fiber development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- regulation of myoblast fusion [ISS]
- regulation of satellite cell proliferation [ISS]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to electrical stimulus involved in regulation of muscle adaptation [ISS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- skeletal muscle tissue development [TAS]
- striated muscle atrophy [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.
Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen with either myogenic bHLH factor alone. This cooperativity required direct interactions between the DNA-binding domains of MEF2 and ... [more]
Cell Dec. 29, 1995; 83(7);1125-36 [Pubmed: 8548800]
Throughput
- Low Throughput
Curated By
- BioGRID