USP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
SMURF1
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- cell differentiation [ISO, ISS]
- negative regulation of ossification [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein export from nucleus [ISO]
- protein localization to cell surface [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IMP, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO, ISS]
- receptor catabolic process [ISO]
- transforming growth factor beta receptor signaling pathway [IBA]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitin specific protease 5 negatively regulates the IFNs-mediated antiviral activity via targeting SMURF1.
Type I interferons are broadly used for antiviral therapy in clinical. However, the IFNs-mediated antiviral efficacy is commonly restricted by negative regulators. Here, we show that the ubiquitin-specific protease 5 (USP5) inhibits the IFNs-induced p-STAT1 activation (phosphorylation at tyrosine site of STAT1) and its downstream antiviral genes expression. We clarify that USP5 physically interacts with SMURF1 (Smad ubiquitination regulating factor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID