BAIT

PDLIM5

ENH, ENH1, LIM, L9
PDZ and LIM domain 5
GO Process (2)
GO Function (3)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CBLL1

HAKAI, RNF188
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.

Shi Y, Wang X, Xu Z, He Y, Guo C, He L, Huan C, Cai C, Huang J, Zhang J, Li Y, Zeng C, Zhang X, Wang L, Ke Y, Cheng H

Transforming growth factor ? (TGF?) signaling plays an important role in regulating tumor malignancy, including in non-small cell lung cancer (NSCLC). The major biological responses of TGF? signaling are determined by the effector proteins SMAD2 and SMAD3. However, the regulators of TGF?-SMAD signaling are not completely revealed yet. Here, we showed that the scaffolding protein PDLIM5 (PDZ and LIM domain ... [more]

J Biol Chem Dec. 02, 2019; 295(40);13798-13811 [Pubmed: 32737199]

Throughput

  • High Throughput

Curated By

  • BioGRID