BAIT
PDLIM5
ENH, ENH1, LIM, L9
PDZ and LIM domain 5
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HERC5
CEB1, CEBP1
HECT and RLD domain containing E3 ubiquitin protein ligase 5
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of defense response to virus [IDA]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells.
Transforming growth factor ? (TGF?) signaling plays an important role in regulating tumor malignancy, including in non-small cell lung cancer (NSCLC). The major biological responses of TGF? signaling are determined by the effector proteins SMAD2 and SMAD3. However, the regulators of TGF?-SMAD signaling are not completely revealed yet. Here, we showed that the scaffolding protein PDLIM5 (PDZ and LIM domain ... [more]
J Biol Chem Dec. 02, 2019; 295(40);13798-13811 [Pubmed: 32737199]
Throughput
- High Throughput
Curated By
- BioGRID