BAIT
NFE2L2
NRF2
nuclear factor, erythroid 2-like 2
GO Process (14)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- cellular response to fluid shear stress [IDA]
- cellular response to hydrogen peroxide [IMP]
- cellular response to laminar fluid shear stress [IMP]
- cellular response to tumor necrosis factor [IMP]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of hydrogen peroxide-induced cell death [IGI]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of gene expression [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [IMP]
- proteasomal ubiquitin-independent protein catabolic process [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein ubiquitination [IDA]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [TAS]
- transcription regulatory region sequence-specific DNA binding [TAS]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [TAS]
- transcription regulatory region sequence-specific DNA binding [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
ZBTB24
BIF1, ICF2, PATZ2, ZNF450
zinc finger and BTB domain containing 24
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
NRF2 (NFE2L2) is a cytoprotective transcription factor associated with >60 human diseases, adverse drug reactions and therapeutic resistance. To provide insight into the complex regulation of NRF2 responses, 1962 predicted NRF2-partner interactions were systematically tested to generate an experimentally defined high-density human NRF2 interactome. Verification and conditional stratification of 46 new NRF2 partners was achieved by co-immunoprecipitation and the novel ... [more]
Redox Biol Dec. 01, 2019; 37();101686 [Pubmed: 32911434]
Throughput
- Low Throughput
Curated By
- BioGRID