RAB1A
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IGI, IMP]
- GTP catabolic process [IDA]
- Golgi organization [IMP]
- Rab protein signal transduction [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- cargo loading into COPII-coated vesicle [IMP]
- cell migration [IMP]
- cilium assembly [IMP]
- defense response to bacterium [IMP]
- endocytosis [IMP]
- growth hormone secretion [IMP]
- interleukin-8 secretion [IMP]
- intracellular protein transport [IBA]
- mitotic cell cycle [TAS]
- positive regulation of glycoprotein metabolic process [IGI]
- vesicle transport along microtubule [IMP]
- vesicle-mediated transport [TAS]
- virion assembly [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
USP2
Gene Ontology Biological Process
- circadian behavior [ISS]
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- locomotor rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of mitotic cell cycle [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- protein stabilization [IDA, IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.
Deubiquitination, the inverse process of ubiquitination, is catalyzed by deubiquitinases (DUBs) that remove ubiquitin from target proteins and subsequently prevent their degradation by proteasomes. Previously, deubiquitination has been found to be involved in hepatocellular carcinoma (HCC) progression. As yet, however, little is known about the exact role of deubiquitination in the development and/or progression of this type of cancer.HCC tissues ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| USP2 RAB1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| USP2 RAB1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID