BAIT

SLC26A4-AS1

SLC26A4 antisense RNA 1

GO Process (0)

GO Function (0)

GO Component (0)

CRISPR Database HGNC Alliance of Genome Resources Entrez Gene Ensembl

Homo sapiens

PREY

HSPB1

CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27

heat shock 27kDa protein 1

Alzheimer's Disease Project

GO Process (21)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

RNA metabolic process [TAS]

cellular component movement [TAS]

cellular response to vascular endothelial growth factor stimulus [IMP]

gene expression [TAS]

intracellular signal transduction [IMP]

mRNA metabolic process [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]

negative regulation of protein kinase activity [ISS]

platelet aggregation [IMP]

positive regulation of angiogenesis [IMP]

positive regulation of blood vessel endothelial cell migration [IMP]

positive regulation of endothelial cell chemotaxis [IMP]

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]

positive regulation of interleukin-1 beta production [ISS]

positive regulation of tumor necrosis factor biosynthetic process [ISS]

regulation of I-kappaB kinase/NF-kappaB signaling [ISS]

regulation of translational initiation [TAS]

response to unfolded protein [NAS]

response to virus [IEP]

retina homeostasis [IEP]

Gene Ontology Molecular Function

identical protein binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase C binding [ISS]
protein kinase C inhibitor activity [ISS]
protein kinase binding [IPI]
ubiquitin binding [ISS]

Gene Ontology Cellular Component

cytoplasm [IDA, TAS]

cytoskeleton [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

proteasome complex [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5.

Yuan J, Song Y, Pan W, Li Y, Xu Y, Xie M, Shen Y, Zhang N, Liu J, Hua H, Wang B, An C, Yang M

Lymph node metastasis is the major adverse feature for recurrence and death of thyroid cancer patients. To identify lncRNAs involved in thyroid cancer metastasis, we systemically screened differentially expressed lncRNAs in lymph node metastasis, thyroid cancer, and normal tissues via RNAseq. We found that lncRNA SLC26A4-AS1 was continuously, significantly down-regulated in normal tissues, thyroid cancer, and lymph node metastasis specimens. ... [more]

Oncogene Dec. 01, 2019; 39(43);6664-6676 [Pubmed: 32939012]

Throughput

High Throughput

Curated By

BioGRID