BAIT
PPM1F
CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2
protein phosphatase, Mg2+/Mn2+ dependent, 1F
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to drug [IDA]
- intrinsic apoptotic signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- peptidyl-threonine dephosphorylation [IDA]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of chemotaxis [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of growth [IMP]
- positive regulation of stress fiber assembly [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARHGEF7
BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, RP11-494P5.1
Rho guanine nucleotide exchange factor (GEF) 7
GO Process (15)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- focal adhesion assembly [IDA]
- lamellipodium assembly [ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of apoptotic process [IMP, TAS]
- positive regulation of fibroblast migration [IDA]
- positive regulation of lamellipodium morphogenesis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
The Rho GTPases are involved in many signaling pathways and cellular functions, including the organization of the actin cytoskeleton, regulation of transcription, cell motility, and cell division. The p21 (Cdc42/Rac)-activated kinase PAK mediates a number of biological effects downstream of these Rho GTPases (reviewed by [1]). The phosphorylation state of mammalian PAK is highly regulated: upon binding of GTPases, PAK ... [more]
Curr. Biol. Feb. 19, 2002; 12(4);317-21 [Pubmed: 11864573]
Throughput
- Low Throughput
Curated By
- BioGRID