BAIT
UBA5
THIFP1, UBE1DC1
ubiquitin-like modifier activating enzyme 5
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ERN1
IRE1, IRE1P, IRE1a, hIRE1p
endoplasmic reticulum to nucleus signaling 1
GO Process (16)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- HAC1-type intron splice site recognition and cleavage [IDA]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, TAS]
- RNA splicing [IMP]
- activation of signaling protein activity involved in unfolded protein response [IDA, TAS]
- cell cycle arrest [ISS]
- cellular protein metabolic process [TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- endothelial cell proliferation [IDA]
- mRNA cleavage [IDA]
- mRNA splicing, via endonucleolytic cleavage and ligation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- positive regulation of RNA splicing [IDA]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- protein phosphorylation [IDA]
- protein trans-autophosphorylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
UFMylation inhibits the proinflammatory capacity of interferon-?-activated macrophages.
Macrophages activated with interferon-? (IFN-?) in combination with other proinflammatory stimuli, such as lipopolysaccharide or tumor necrosis factor-? (TNF-?), respond with transcriptional and cellular changes that enhance clearance of intracellular pathogens at the risk of damaging tissues. IFN-? effects must therefore be carefully balanced with inhibitory mechanisms to prevent immunopathology. We performed a genome-wide CRISPR knockout screen in a macrophage ... [more]
Proc Natl Acad Sci U S A Dec. 05, 2020; 118(1); [Pubmed: 33372156]
Throughput
- Low Throughput
Ontology Terms
- biological process: response to interferon-gamma (GO:0034341)
Additional Notes
- Editing Ern1 in Uba5-Cas9-KO cells decreased NO production and restored iNOS protein levels in Uba5-KO cells in response to both IFNgamma and LPS
Curated By
- BioGRID