BAIT
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (70)
GO Function (26)
GO Component (25)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- adult locomotory behavior [ISO]
- aging [IEP]
- behavioral response to cocaine [IMP]
- calcium ion homeostasis [ISO]
- cellular response to copper ion [ISO]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to oxidative stress [ISO]
- dopamine biosynthetic process [ISO]
- dopamine metabolic process [ISO]
- fatty acid metabolic process [ISO]
- long-term synaptic potentiation [ISO]
- membrane organization [ISO]
- microglial cell activation [ISO]
- mitochondrial ATP synthesis coupled electron transport [ISO]
- mitochondrial membrane organization [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dopamine metabolic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [ISO]
- negative regulation of exocytosis [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of microtubule polymerization [ISO]
- negative regulation of monooxygenase activity [ISO]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of norepinephrine uptake [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of serotonin uptake [ISO]
- negative regulation of thrombin receptor signaling pathway [ISO]
- negative regulation of transporter activity [ISO]
- neutral lipid metabolic process [ISO]
- oxidation-reduction process [ISO]
- phospholipid metabolic process [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of glutathione peroxidase activity [ISO]
- positive regulation of hydrogen peroxide catabolic process [ISO]
- positive regulation of inositol phosphate biosynthetic process [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission [ISO]
- protein destabilization [ISO]
- receptor internalization [ISO]
- regulation of acyl-CoA biosynthetic process [ISO]
- regulation of dopamine secretion [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of glutamate secretion [ISO]
- regulation of locomotion [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of macrophage activation [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuron death [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of neurotransmitter secretion [ISO]
- regulation of phospholipase activity [ISO]
- response to cocaine [IEP]
- response to drug [ISO]
- response to interferon-gamma [ISO]
- response to interleukin-1 [ISO]
- response to iron(II) ion [ISO]
- response to lipopolysaccharide [ISO]
- response to magnesium ion [ISO]
- synapse organization [ISO]
- synaptic transmission [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic vesicle endocytosis [ISO]
- synaptic vesicle transport [ISO]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [ISO]
- beta-tubulin binding [IDA]
- calcium ion binding [ISO]
- copper ion binding [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [IPI]
- fatty acid binding [ISO]
- ferrous iron binding [ISO]
- histone binding [ISO]
- identical protein binding [ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [IDA]
- oxidoreductase activity [ISO]
- phospholipase D inhibitor activity [ISO]
- phospholipase binding [IPI]
- phospholipid binding [IDA, ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tau protein binding [ISO]
- zinc ion binding [ISO]
- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [ISO]
- beta-tubulin binding [IDA]
- calcium ion binding [ISO]
- copper ion binding [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [IPI]
- fatty acid binding [ISO]
- ferrous iron binding [ISO]
- histone binding [ISO]
- identical protein binding [ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [IDA]
- oxidoreductase activity [ISO]
- phospholipase D inhibitor activity [ISO]
- phospholipase binding [IPI]
- phospholipid binding [IDA, ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tau protein binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin cytoskeleton [ISO]
- axon [ISO]
- axon terminus [IDA]
- cell [ISO]
- cell cortex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle membrane [IDA]
- cytoskeleton [ISO]
- cytosol [IDA, ISO]
- fibril [ISO]
- growth cone [IDA, ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [IDA]
- mitochondrion [IDA, ISO]
- nuclear outer membrane [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- platelet alpha granule membrane [ISO]
- ribosome [IDA]
- rough endoplasmic reticulum [IDA]
- synapse [ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
Rattus norvegicus
PREY
TH
The
tyrosine hydroxylase
GO Process (64)
GO Function (11)
GO Component (16)
Gene Ontology Biological Process
- catecholamine biosynthetic process [IDA]
- cellular response to alkaloid [IEP]
- cellular response to drug [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to manganese ion [IEP]
- cellular response to nicotine [IEP]
- cerebral cortex development [IEP]
- circadian sleep/wake cycle [IEP]
- cognition [IEP]
- dopamine biosynthetic process [ISO]
- dopamine biosynthetic process from tyrosine [IDA, IMP, ISO]
- eating behavior [ISO]
- embryonic camera-type eye morphogenesis [ISO]
- epinephrine biosynthetic process [ISO]
- eye photoreceptor cell development [ISO]
- fatty acid metabolic process [IEP]
- glycoside metabolic process [IEP]
- heart development [IDA, ISO]
- isoquinoline alkaloid metabolic process [IEP]
- learning [ISO]
- locomotory behavior [ISO]
- mating behavior [ISO]
- memory [ISO]
- multicellular organismal aging [IEP]
- norepinephrine biosynthetic process [ISO]
- organ morphogenesis [ISO]
- phthalate metabolic process [IEP]
- phytoalexin metabolic process [IEP]
- protein homotetramerization [TAS]
- regulation of heart contraction [ISO]
- response to activity [IEP]
- response to amphetamine [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to ethanol [IEP, ISO]
- response to ether [IEP]
- response to growth factor [IEP]
- response to herbicide [IEP]
- response to hypoxia [IDA, IEP, ISO]
- response to immobilization stress [IEP]
- response to insecticide [IEP]
- response to isolation stress [IEP]
- response to light stimulus [IEP]
- response to lipopolysaccharide [IEP]
- response to metal ion [IEP]
- response to nicotine [IEP]
- response to nutrient levels [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to pyrethroid [IEP]
- response to salt stress [IEP]
- response to steroid hormone [IEP]
- response to water deprivation [IEP]
- response to zinc ion [IEP]
- sensory perception of sound [IEP]
- social behavior [IEP]
- sphingolipid metabolic process [IEP]
- synaptic transmission, dopaminergic [ISO]
- synaptic vesicle amine transport [IDA]
- terpene metabolic process [IEP]
- visual perception [ISO]
Gene Ontology Molecular Function- amino acid binding [IDA, IPI]
- dopamine binding [IPI]
- enzyme binding [ISO]
- ferric iron binding [IDA]
- ferrous iron binding [IDA]
- monooxygenase activity [IDA]
- oxygen binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tetrahydrobiopterin binding [IDA]
- tyrosine 3-monooxygenase activity [IDA, ISO]
- amino acid binding [IDA, IPI]
- dopamine binding [IPI]
- enzyme binding [ISO]
- ferric iron binding [IDA]
- ferrous iron binding [IDA]
- monooxygenase activity [IDA]
- oxygen binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tetrahydrobiopterin binding [IDA]
- tyrosine 3-monooxygenase activity [IDA, ISO]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytoplasmic vesicle [ISO]
- cytoplasmic vesicle membrane [IDA]
- cytosol [IDA]
- dendrite [IDA]
- melanosome membrane [ISO]
- mitochondrion [IDA]
- neuron projection [IDA, ISO]
- neuronal cell body [IDA]
- nucleus [ISO]
- perikaryon [IDA, ISO]
- smooth endoplasmic reticulum [ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A role for alpha-synuclein in the regulation of dopamine biosynthesis.
The alpha-synuclein gene is implicated in the pathogenesis of Parkinson's disease. Although alpha-synuclein function is uncertain, the protein has homology to the chaperone molecule 14-3-3. In addition, alpha-synuclein can bind to 14-3-3, and both alpha-synuclein and 14-3-3 bind to many of the same proteins. Because 14-3-3 binds to and activates tyrosine hydroxylase, the rate-limiting enzyme in dopamine (DA) biosynthesis, we ... [more]
J. Neurosci. Apr. 15, 2002; 22(8);3090-9 [Pubmed: 11943812]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TH SNCA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID