BAIT
TRIM27
RFP, RNF76, DAAP-182E11.3
tripartite motif containing 27
GO Process (18)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- Arp2/3 complex-mediated actin nucleation [IDA]
- cell proliferation [TAS]
- innate immune response [IDA]
- interferon-gamma secretion [IMP]
- negative regulation of adaptive immune response [IMP]
- negative regulation of calcium ion import [IMP]
- negative regulation of gene expression, epigenetic [IDA]
- negative regulation of interleukin-2 secretion [IMP]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of tumor necrosis factor production [IMP]
- negative regulation of viral transcription [IDA]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- protein K63-linked ubiquitination [IMP]
- protein trimerization [IDA]
- retrograde transport, endosome to Golgi [IDA]
- spermatogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PAK1
PAKalpha
p21 protein (Cdc42/Rac)-activated kinase 1
GO Process (21)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- MAPK cascade [IDA]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- actin cytoskeleton reorganization [IDA, IMP]
- axon guidance [TAS]
- branching morphogenesis of an epithelial tube [IMP]
- innate immune response [TAS]
- mitotic cell cycle [IBA]
- negative regulation of cell proliferation involved in contact inhibition [IMP]
- neuron projection morphogenesis [ISS]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of intracellular estrogen receptor signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of stress fiber assembly [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- signal transduction by phosphorylation [IBA]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.
In the current study, we aimed to explore the correlation between TRIM27 and breast cancer prognosis, as well as the functions of TRIM27 in breast cancer and their underlying mechanisms. Bioinformatics analyses were used to examine the correlation between TRIM27 and breast cancer prognosis. Moreover, TRIM27 knockdown and overexpression in breast cancer cells were performed to investigate its functions in ... [more]
Mol Ther Nucleic Acids Dec. 04, 2020; 22();910-923 [Pubmed: 33251042]
Throughput
- Low Throughput
Curated By
- BioGRID