BAIT
HTRA4
HtrA serine peptidase 4
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TAOK1
KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
TAO kinase 1
GO Process (11)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- MAPK cascade [IBA]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- execution phase of apoptosis [IDA]
- mitotic cell cycle [TAS]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein phosphorylation [NAS]
- regulation of cytoskeleton organization [ISS]
- spindle checkpoint [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
The human HtrA4 protein, belonging to the HtrA family of proteases/chaperones, participates in oncogenesis and placentation, and plays a role in preeclampsia. As the knowledge concerning the biochemical features of this protein and its role at the molecular level is limited, in this work we characterized the HtrA4 molecule and searched for its cellular function. We found that recombinant HtrA4 ... [more]
J Proteomics Dec. 30, 2018; 209();103505 [Pubmed: 31470122]
Throughput
- Low Throughput
Curated By
- BioGRID