BAIT
HTRA4
HtrA serine peptidase 4
GO Process (2)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TGFB3
ARVD, ARVD1, RNHF, TGF-beta3
transforming growth factor, beta 3
GO Process (37)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- SMAD protein signal transduction [IBA]
- blood coagulation [TAS]
- cell-cell junction organization [IDA]
- detection of hypoxia [IDA]
- extracellular matrix organization [TAS]
- face morphogenesis [IMP]
- in utero embryonic development [ISS]
- lung alveolus development [ISS]
- mammary gland development [ISS]
- negative regulation of DNA replication [IMP]
- negative regulation of cell proliferation [ISS]
- negative regulation of macrophage cytokine production [IDA]
- negative regulation of neuron apoptotic process [ISS]
- odontogenesis [NAS]
- ossification involved in bone remodeling [IEP]
- palate development [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA replication [IMP]
- positive regulation of SMAD protein import into nucleus [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of bone mineralization [IEP]
- positive regulation of collagen biosynthetic process [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA, ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISS]
- positive regulation of protein secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- response to hypoxia [IDA]
- response to progesterone [IDA]
- salivary gland morphogenesis [IEP]
- transforming growth factor beta receptor signaling pathway [IDA]
- uterine wall breakdown [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
The human HtrA4 protein, belonging to the HtrA family of proteases/chaperones, participates in oncogenesis and placentation, and plays a role in preeclampsia. As the knowledge concerning the biochemical features of this protein and its role at the molecular level is limited, in this work we characterized the HtrA4 molecule and searched for its cellular function. We found that recombinant HtrA4 ... [more]
J Proteomics Dec. 30, 2018; 209();103505 [Pubmed: 31470122]
Throughput
- Low Throughput
Curated By
- BioGRID