BAIT
TRIM9
RNF91, SPRING
tripartite motif containing 9
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ARRB2
AI326910, AW122872, DN-491F10.4
arrestin, beta 2
GO Process (38)
GO Function (18)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- adult walking behavior [IMP]
- cell chemotaxis [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of natural killer cell mediated cytotoxicity [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of release of cytochrome c from mitochondria [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase B signaling [IMP, ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of synaptic transmission, dopaminergic [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor internalization [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of protein phosphorylation [IDA, IGI]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- 14-3-3 protein binding [ISO]
- D1 dopamine receptor binding [ISO]
- G-protein coupled receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- enzyme binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein complex scaffold [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [IPI]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- type 2A serotonin receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.
TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon guidance cue netrin-1. Deletion of murine Trim9 or Trim67 results in neuroanatomical defects and striking behavioral deficits, particularly in spatial learning and memory. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome ... [more]
Mol Biol Cell Dec. 15, 2020; 32(4);314-330 [Pubmed: 33378226]
Throughput
- Low Throughput
Additional Notes
- species of bait is unclear
Curated By
- BioGRID