BAIT
TRIM9
RNF91, SPRING
tripartite motif containing 9
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
STOML2
0610038F01Rik, MSLP2, SLP-2, RP23-124L1.8
stomatin (Epb7.2)-like 2
GO Process (15)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [IMP]
- T cell receptor signaling pathway [ISO]
- cellular calcium ion homeostasis [ISO]
- interleukin-2 production [IMP]
- lipid localization [IMP]
- mitochondrial ATP synthesis coupled proton transport [IMP, ISO]
- mitochondrial calcium ion transport [ISO]
- mitochondrial protein processing [IMP]
- mitochondrion localization [IMP]
- mitochondrion organization [ISO]
- positive regulation of cardiolipin metabolic process [ISO]
- positive regulation of mitochondrial DNA replication [ISO]
- positive regulation of mitochondrial membrane potential [ISO]
- protein oligomerization [ISO]
- stress-induced mitochondrial fusion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- T cell receptor complex [ISO]
- actin cytoskeleton [ISO]
- cell [IMP]
- extrinsic component of plasma membrane [IDA, ISO]
- immunological synapse [ISO]
- intracellular [IMP]
- membrane raft [ISO]
- mitochondrial inner membrane [IDA, ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA, IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.
TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon guidance cue netrin-1. Deletion of murine Trim9 or Trim67 results in neuroanatomical defects and striking behavioral deficits, particularly in spatial learning and memory. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome ... [more]
Mol Biol Cell Dec. 15, 2020; 32(4);314-330 [Pubmed: 33378226]
Throughput
- Low Throughput
Additional Notes
- species of bait is unclear
Curated By
- BioGRID