BAIT
TRIM67
TNL
tripartite motif containing 67
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ARHGEF2
AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [IPI, ISO]
- cell morphogenesis [IDA, ISO]
- cellular response to muramyl dipeptide [ISO]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of microtubule depolymerization [ISO]
- negative regulation of neurogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [IDA, ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rho protein signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.
TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon guidance cue netrin-1. Deletion of murine Trim9 or Trim67 results in neuroanatomical defects and striking behavioral deficits, particularly in spatial learning and memory. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome ... [more]
Mol Biol Cell Dec. 15, 2020; 32(4);314-330 [Pubmed: 33378226]
Throughput
- Low Throughput
Additional Notes
- species of bait is unclear
Curated By
- BioGRID