An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Global proteomics of Ubqln2-based murine models of ALS.

Whiteley AM, Prado MA, de Poot SAH, Paulo JA, Ashton M, Dominguez S, Weber M, Ngu H, Szpyt J, Jedrychowski MP, Easton A, Gygi SP, Kurz T, Monteiro MJ, Brown EJ, Finley D

Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation. UBQLN2 mutations result in familial amyotrophic lateral sclerosis ... [more]

J Biol Chem Dec. 06, 2020; 296();100153 [Pubmed: 33277362]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

UBQLN1

Gene Ontology Biological Process

Gene Ontology Molecular Function

kinase binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

DST

Gene Ontology Biological Process

Gene Ontology Molecular Function

integrin binding [IPI]microtubule plus-end binding [IDA]protein C-terminus binding [IPI]protein binding [IPI]protein homodimerization activity [IDA]

Gene Ontology Cellular Component

Affinity Capture-MS

Publication

Global proteomics of Ubqln2-based murine models of ALS.

Throughput

Curated By

kinase binding [IPI]
protein binding [IPI]

integrin binding [IPI]
microtubule plus-end binding [IDA]
protein C-terminus binding [IPI]
protein binding [IPI]
protein homodimerization activity [IDA]