Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Physiological Tau Interactome in Brain and Its Link to Tauopathies.

Sinsky J, Majerova P, Kovac A, Kotlyar M, Jurisica I, Hanes J

Alzheimer's disease (AD) and most of the other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all of these diseases is tau pathology, but its connection with disease progress has not been completely understood so far. Therefore, uncovering novel tau-interacting partners and pathology affected molecular pathways can reveal the causes of diseases as well ... [more]

J Proteome Res Dec. 05, 2019; 19(6);2429-2442 [Pubmed: 32357304]

Throughput

  • Low Throughput

Curated By

  • BioGRID