MAPT
Gene Ontology Biological Process
- adult walking behavior [ISO]
- apoptotic process [IDA]
- axon cargo transport [ISO]
- axon extension [ISO]
- axonogenesis [ISO]
- brain development [IEP]
- female pregnancy [IEP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- microtubule cytoskeleton organization [ISO, ISS]
- microtubule-based process [NAS]
- mitochondrion transport along microtubule [ISO]
- negative regulation of intracellular transport [ISO]
- neuron differentiation [NAS]
- neuron migration [ISO]
- positive regulation of axon extension [ISO, ISS]
- positive regulation of microtubule polymerization [ISO, ISS]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [ISO]
- response to nutrient [IDA]
- response to organic substance [IDA]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
Gene Ontology Cellular Component
- axon [IDA, ISO, ISS]
- axonal growth cone [IDA]
- axoneme [ISO]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO, ISS]
- intracellular [ISO]
- microtubule cytoskeleton [ISO]
- neuron projection [IDA]
- nuclear periphery [ISO]
- nucleus [ISO]
- plasma membrane [ISO, ISS]
- postsynaptic density [ISO]
- tubulin complex [ISO, ISS]
NPTX1
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physiological Tau Interactome in Brain and Its Link to Tauopathies.
Alzheimer's disease (AD) and most of the other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all of these diseases is tau pathology, but its connection with disease progress has not been completely understood so far. Therefore, uncovering novel tau-interacting partners and pathology affected molecular pathways can reveal the causes of diseases as well ... [more]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Higher confidence interactions validated by low throughput experiments (Co-IP and Co-localization).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPT NPTX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID