BAIT
MAPT
Mtapt, RNPTAU, pTau, rCG_32645
microtubule-associated protein tau
GO Process (20)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- adult walking behavior [ISO]
- apoptotic process [IDA]
- axon cargo transport [ISO]
- axon extension [ISO]
- axonogenesis [ISO]
- brain development [IEP]
- female pregnancy [IEP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- microtubule cytoskeleton organization [ISO, ISS]
- microtubule-based process [NAS]
- mitochondrion transport along microtubule [ISO]
- negative regulation of intracellular transport [ISO]
- neuron differentiation [NAS]
- neuron migration [ISO]
- positive regulation of axon extension [ISO, ISS]
- positive regulation of microtubule polymerization [ISO, ISS]
- regulation of autophagy [ISO]
- regulation of microtubule-based movement [ISO]
- response to nutrient [IDA]
- response to organic substance [IDA]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
- SH3 domain binding [ISO]
- apolipoprotein binding [ISO]
- enzyme binding [IPI, ISO]
- lipoprotein particle binding [ISO]
- microtubule binding [IDA, ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IMP]
- protein kinase binding [IPI, ISO]
- protein phosphatase 2A binding [IPI]
Gene Ontology Cellular Component
- axon [IDA, ISO, ISS]
- axonal growth cone [IDA]
- axoneme [ISO]
- cell [ISO]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- growth cone [ISO, ISS]
- intracellular [ISO]
- microtubule cytoskeleton [ISO]
- neuron projection [IDA]
- nuclear periphery [ISO]
- nucleus [ISO]
- plasma membrane [ISO, ISS]
- postsynaptic density [ISO]
- tubulin complex [ISO, ISS]
Rattus norvegicus
PREY
PRDX5
Aoeb166
peroxiredoxin 5
GO Process (11)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- NADPH oxidation [ISO]
- cellular response to reactive oxygen species [ISO]
- hydrogen peroxide catabolic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of oxidoreductase activity [ISO]
- negative regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of collagen biosynthetic process [ISO]
- reactive nitrogen species metabolic process [ISO]
- regulation of apoptosis involved in tissue homeostasis [ISO]
- response to oxidative stress [ISO]
Gene Ontology Molecular Function- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO]
- RNA polymerase III regulatory region DNA binding [ISO]
- antioxidant activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- peroxidase activity [ISO]
- peroxiredoxin activity [ISO]
- peroxynitrite reductase activity [ISO]
- protein dimerization activity [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Physiological Tau Interactome in Brain and Its Link to Tauopathies.
Alzheimer's disease (AD) and most of the other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all of these diseases is tau pathology, but its connection with disease progress has not been completely understood so far. Therefore, uncovering novel tau-interacting partners and pathology affected molecular pathways can reveal the causes of diseases as well ... [more]
J Proteome Res Dec. 05, 2019; 19(6);2429-2442 [Pubmed: 32357304]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
Curated By
- BioGRID