BAIT
FZR1
CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1
fizzy/cell division cycle 20 related 1 (Drosophila)
GO Process (9)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IDA]
- activation of anaphase-promoting complex activity [IDA]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA, TAS]
- mitotic cell cycle [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of protein catabolic process [IGI]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein K11-linked ubiquitination [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCKAP1L
HEM1
NCK-associated protein 1-like
GO Process (31)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- B cell receptor signaling pathway [IMP]
- T cell homeostasis [ISS]
- actin polymerization-dependent cell motility [IMP]
- chemotaxis [IDA]
- cortical actin cytoskeleton organization [IMP]
- erythrocyte development [IEP]
- maintenance of cell polarity [IMP]
- myeloid cell homeostasis [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of myosin-light-chain-phosphatase activity [IMP]
- neutrophil chemotaxis [IDA]
- positive regulation of B cell differentiation [ISS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of CD4-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of CD8-positive, alpha-beta T cell differentiation [ISS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of T cell proliferation [ISS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of erythrocyte differentiation [ISS]
- positive regulation of gamma-delta T cell differentiation [ISS]
- positive regulation of lymphocyte differentiation [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of phagocytosis, engulfment [ISS]
- positive regulation of phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- protein complex assembly [ISS]
- response to drug [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By combining orthogonal features of known substrates, we predicted APC/C substrates in silico. This analysis identified many known substrates and suggested numerous candidates. Unexpectedly, chromatin regulatory proteins are enriched among putative ... [more]
PLoS Biol Dec. 01, 2019; 18(12);e3000975 [Pubmed: 33306668]
Throughput
- Low Throughput
Curated By
- BioGRID