DAPK3
Gene Ontology Biological Process
- apoptotic process [IMP, ISO]
- apoptotic signaling pathway [ISO]
- cellular response to interferon-gamma [ISO]
- intracellular signal transduction [IDA, ISO]
- negative regulation of translation [ISO]
- neuron differentiation [IEP]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein autophosphorylation [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of actin cytoskeleton reorganization [ISO]
- regulation of cell shape [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of myosin II filament organization [ISO]
Gene Ontology Molecular Function
AATF
Gene Ontology Biological Process
- cell adhesion [ISO]
- cellular response to DNA damage stimulus [ISO]
- embryonic cleavage [ISO]
- negative regulation of amyloid precursor protein biosynthetic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of superoxide anion generation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of mitotic cell cycle [ISO]
- ribosome biogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- focal adhesion [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.
Dlk, also known as ZIP kinase, is a serine/threonine kinase that is tightly associated with nuclear structures. Under certain conditions, which require cytoplasmic localization, Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF), a nuclear phosphoprotein of 523 amino acids. The 1.8 kb ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAPK3 AATF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| DAPK3 AATF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID