DAPK3
Gene Ontology Biological Process
- apoptotic process [IMP, ISO]
- apoptotic signaling pathway [ISO]
- cellular response to interferon-gamma [ISO]
- intracellular signal transduction [IDA, ISO]
- negative regulation of translation [ISO]
- neuron differentiation [IEP]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein autophosphorylation [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of actin cytoskeleton reorganization [ISO]
- regulation of cell shape [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of myosin II filament organization [ISO]
Gene Ontology Molecular Function
TPM1
Gene Ontology Biological Process
- actin filament capping [IDA]
- cardiac muscle contraction [IDA, ISO]
- cellular response to reactive oxygen species [ISO]
- in utero embryonic development [ISO]
- muscle contraction [TAS]
- muscle filament sliding [IDA]
- negative regulation of cell migration [IGI]
- positive regulation of ATPase activity [IDA, IMP]
- positive regulation of cell adhesion [IGI]
- positive regulation of heart rate by epinephrine [ISO]
- positive regulation of stress fiber assembly [IGI]
- regulation of ATPase activity [IDA]
- ruffle organization [IGI]
- sarcomere organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.
Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. Moreover, it possesses a leucine zipper which mediates interaction with transcription factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAPK3 TPM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID