DAPK3
Gene Ontology Biological Process
- apoptotic process [IMP, ISO]
- apoptotic signaling pathway [ISO]
- cellular response to interferon-gamma [ISO]
- intracellular signal transduction [IDA, ISO]
- negative regulation of translation [ISO]
- neuron differentiation [IEP]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein autophosphorylation [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of actin cytoskeleton reorganization [ISO]
- regulation of cell shape [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of myosin II filament organization [ISO]
Gene Ontology Molecular Function
AATF
Gene Ontology Biological Process
- cell adhesion [ISO]
- cellular response to DNA damage stimulus [ISO]
- embryonic cleavage [ISO]
- negative regulation of amyloid precursor protein biosynthetic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of superoxide anion generation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of mitotic cell cycle [ISO]
- ribosome biogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- focal adhesion [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.
Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. Moreover, it possesses a leucine zipper which mediates interaction with transcription factor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DAPK3 AATF | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| DAPK3 AATF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID