HOMER1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- behavioral response to cocaine [ISO]
- chemical homeostasis within a tissue [ISO]
- circadian rhythm [IEP]
- positive regulation of calcium ion transport [ISO]
- protein localization to synapse [IDA]
- regulation of calcium ion import [ISO]
- regulation of cation channel activity [ISO]
- regulation of store-operated calcium entry [IBA, ISO]
- response to calcium ion [ISO]
- response to cocaine [IEP]
- response to nicotine [IEP]
- skeletal muscle contraction [ISO]
- skeletal muscle fiber development [ISO]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
SHANK1
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [ISO, ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISO, ISS]
- determination of affect [ISO]
- habituation [ISO, ISS]
- long-term memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- olfactory behavior [ISO, ISS]
- positive regulation of dendritic spine development [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- protein complex assembly [IDA]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- righting reflex [ISO, ISS]
- social behavior [ISO]
- synapse maturation [IDA]
- vocalization behavior [ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- dendrite [ISO, NAS]
- dendritic spine [IDA, ISO]
- excitatory synapse [ISO, ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISO, ISS]
- membrane [ISO]
- neuron projection [ISO, ISS]
- neuronal postsynaptic density [ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby coupling these receptors ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOMER1 SHANK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SHANK1 HOMER1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HOMER1 SHANK1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID