HOMER1
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- behavioral response to cocaine [ISO]
- chemical homeostasis within a tissue [ISO]
- circadian rhythm [IEP]
- positive regulation of calcium ion transport [ISO]
- protein localization to synapse [IDA]
- regulation of calcium ion import [ISO]
- regulation of cation channel activity [ISO]
- regulation of store-operated calcium entry [IBA, ISO]
- response to calcium ion [ISO]
- response to cocaine [IEP]
- response to nicotine [IEP]
- skeletal muscle contraction [ISO]
- skeletal muscle fiber development [ISO]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
SHANK3
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- N-methyl-D-aspartate receptor clustering [ISO, ISS]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO, ISS]
- brain morphogenesis [ISO, ISS]
- dendritic spine morphogenesis [ISO, ISS]
- embryonic epithelial tube formation [ISO]
- guanylate kinase-associated protein clustering [ISO, ISS]
- learning [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- negative regulation of cell volume [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- positive regulation of dendritic spine development [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO, ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- positive regulation of synapse structural plasticity [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density assembly [ISO, ISS]
- protein oligomerization [IDA]
- regulation of behavioral fear response [ISO, ISS]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of long term synaptic depression [ISO, ISS]
- regulation of long-term synaptic potentiation [ISO, ISS]
- social behavior [ISO, ISS]
- striatal medium spiny neuron differentiation [ISO, ISS]
- synapse assembly [ISO, ISS]
- vocal learning [ISO]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby coupling these receptors ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOMER1 SHANK3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID