BNIP3
Gene Ontology Biological Process
- apoptotic process [IPI]
- cell death [ISS]
- cellular response to cobalt ion [IMP]
- cellular response to hypoxia [IMP]
- cellular response to mechanical stimulus [IEP]
- defense response to virus [IDA]
- granzyme-mediated apoptotic signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to hypoxia [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- mitochondrial outer membrane permeabilization [IDA]
- mitochondrial protein catabolic process [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of membrane potential [IDA]
- negative regulation of mitochondrial fusion [IDA]
- neuron apoptotic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of autophagy [TAS]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of programmed cell death [IDA]
- positive regulation of protein complex disassembly [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to hypoxia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BNIP3
Gene Ontology Biological Process
- apoptotic process [IPI]
- cell death [ISS]
- cellular response to cobalt ion [IMP]
- cellular response to hypoxia [IMP]
- cellular response to mechanical stimulus [IEP]
- defense response to virus [IDA]
- granzyme-mediated apoptotic signaling pathway [IDA]
- intrinsic apoptotic signaling pathway in response to hypoxia [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- mitochondrial outer membrane permeabilization [IDA]
- mitochondrial protein catabolic process [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of membrane potential [IDA]
- negative regulation of mitochondrial fusion [IDA]
- neuron apoptotic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of autophagy [TAS]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of programmed cell death [IDA]
- positive regulation of protein complex disassembly [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to hypoxia [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.
Nip3 (nineteen kD interacting protein-3) is an E1B 19K and Bcl-2 binding protein of unknown function. Nip3 is detected as both a 60- and 30-kD protein in vivo and in vitro and exhibits strong homologous interaction in a yeast two-hybrid system indicating that it can homodimerize. Nip3 is expressed in mitochondria and a mutant (Nip3(163)) lacking the putative transmembrane domain ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BNIP3 BNIP3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| BNIP3 BNIP3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| BNIP3 BNIP3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2741405 | |
| BNIP3 BNIP3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| BNIP3 BNIP3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| BNIP3 BNIP3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID