GFRA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GDNF
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISO, ISS]
- cell proliferation [IDA]
- cellular response to dexamethasone stimulus [IDA]
- enteric nervous system development [ISO, ISS]
- mRNA stabilization [ISO, ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- metanephros development [ISO, ISS]
- midbrain development [IEP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- nervous system development [ISO, TAS]
- neural crest cell migration [ISO, ISS]
- neuron differentiation [IDA]
- neuron projection development [ISO, ISS]
- organ induction [ISO]
- peripheral nervous system development [ISO]
- peristalsis [ISO, ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA, IMP, ISO]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- positive regulation of monooxygenase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of ureteric bud formation [ISO, ISS]
- postganglionic parasympathetic nervous system development [ISO, ISS]
- postsynaptic membrane organization [ISO]
- regulation of dopamine uptake involved in synaptic transmission [ISO, ISS]
- regulation of morphogenesis of a branching structure [ISO, ISS]
- regulation of ureteric bud formation [IDA]
- response to wounding [IDA]
- retina development in camera-type eye [IEP]
- sympathetic nervous system development [ISO, ISS]
- ureteric bud development [ISO]
- ureteric bud formation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.
We report the expression cloning and characterization of GDNFR-alpha, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF). GDNFR-alpha binds GDNF specifically and mediates activation of the Ret protein-tyrosine kinase (PTK). Treatment of Neuro-2a cells expressing GDNFR-alpha with GDNF rapidly stimulates Ret autophosphorylation. Ret is also activated by treatment with a combination of GDNF and soluble ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GFRA1 GDNF | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID