BAIT
CTTN
EMS1
cortactin
GO Process (9)
GO Function (1)
GO Component (12)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISS]
- cell motility [ISS]
- focal adhesion assembly [ISS]
- intracellular protein transport [IMP]
- lamellipodium organization [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of actin filament polymerization [ISS]
- receptor-mediated endocytosis [ISS]
- regulation of axon extension [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARPC4
ARC20, P20-ARC
actin related protein 2/3 complex, subunit 4, 20kDa
GO Process (4)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.
Cortactin is an actin-binding protein that is enriched within the lamellipodia of motile cells and in neuronal growth cones. Here, we report that cortactin is localized with the actin-related protein (Arp) 2/3 complex at sites of actin polymerization within the lamellipodia. Two distinct sequence motifs of cortactin contribute to its interaction with the cortical actin network: the fourth of six ... [more]
J. Cell Biol. Oct. 02, 2000; 151(1);29-40 [Pubmed: 11018051]
Throughput
- Low Throughput
Curated By
- BioGRID