BAIT
HMGB2
HMG2
high mobility group box 2
GO Process (22)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- DNA ligation involved in DNA repair [ISS]
- DNA topological change [ISS]
- V(D)J recombination [ISS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- base-excision repair, DNA ligation [IDA]
- cell chemotaxis [IDA]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to lipopolysaccharide [IEP]
- chromatin organization [NAS]
- chromatin remodeling [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- nucleosome assembly [NAS]
- positive chemotaxis [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of nuclease activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IMP]
- DNA binding, bending [IDA]
- RAGE receptor binding [IGI]
- chemoattractant activity [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IDA]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IMP]
- DNA binding, bending [IDA]
- RAGE receptor binding [IGI]
- chemoattractant activity [IDA]
- chromatin binding [IBA]
- damaged DNA binding [IDA]
- double-stranded DNA binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [ISS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
FLNA
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, XX-FW83128A1.1
filamin A, alpha
GO Process (19)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications.
High mobility group box B (HMGB) proteins are pivotal in the development of cancer. Although the proteomics of prostate cancer (PCa) cells has been reported, the involvement of HMGB proteins and their interactome in PCa is an unexplored field of considerable interest. We describe herein the results of the first HMGB1/HMGB2 interactome approach to PCa. Libraries constructed from the PCa ... [more]
Cancers (Basel) Nov. 05, 2019; 11(11); [Pubmed: 31694235]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLNA HMGB2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1444840 |
Curated By
- BioGRID