BAIT
FMR1
FMRP, FRAXA, POF, POF1
fragile X mental retardation 1
GO Process (2)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZFPM2
DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2
zinc finger protein, FOG family member 2
GO Process (8)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- blood coagulation [TAS]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract septum morphogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- right ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA]
- RNA polymerase II transcription coactivator activity [NAS]
- RNA polymerase II transcription factor binding [IBA]
- protein binding [IPI]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA]
- RNA polymerase II transcription coactivator activity [NAS]
- RNA polymerase II transcription factor binding [IBA]
- protein binding [IPI]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- zinc ion binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IBA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID