BAIT
FXR1
FXR1P
fragile X mental retardation, autosomal homolog 1
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
DEAF1
MRD24, NUDR, SPN, ZMYND5
DEAF1 transcription factor
GO Process (7)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- embryonic skeletal system development [ISS]
- germ cell development [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- neural tube closure [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of mammary gland epithelial cell proliferation [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID