BAIT
LMNA
Dhe
lamin A
GO Process (13)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- establishment of cell polarity [NAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- muscle organ development [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- nuclear envelope organization [IGI]
- nucleus organization [IMP]
- positive regulation of cell aging [ISO]
- protein localization to nucleus [IMP]
- regulation of cell migration [IMP]
- regulation of protein localization to nucleus [IMP]
- sterol regulatory element binding protein import into nucleus [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KAT2B
A930006P13Rik, AI461839, AW536563, Pcaf, p/CAF
K(lysine) acetyltransferase 2B
GO Process (21)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cellular response to insulin stimulus [ISO]
- chromatin remodeling [ISO]
- histone H3 acetylation [ISO]
- histone H3-K9 acetylation [IGI]
- histone acetylation [IDA]
- internal peptidyl-lysine acetylation [IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- peptidyl-lysine acetylation [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of histone H3-K14 acetylation [ISO]
- positive regulation of histone H3-K9 acetylation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasodilation [ISO]
- protein acetylation [ISO, TAS]
- regulation of protein ADP-ribosylation [ISO]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation.
Lamin A/C has been implicated in the epigenetic regulation of muscle gene expression through dynamic interaction with chromatin domains and epigenetic enzymes. We previously showed that lamin A/C interacts with histone deacetylase 2 (HDAC2). In this study, we deepened the relevance and regulation of lamin A/C-HDAC2 interaction in human muscle cells. We present evidence that HDAC2 binding to lamina A/C ... [more]
Cells Dec. 20, 2019; 9(7); [Pubmed: 32698523]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay
Curated By
- BioGRID