BAIT
HOXA1
BSAS, HOX1, HOX1F
homeobox A1
GO Process (16)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- abducens nerve formation [IMP]
- anatomical structure morphogenesis [IMP]
- artery development [IMP]
- artery morphogenesis [IMP]
- cochlea development [IMP]
- cochlea morphogenesis [IMP]
- cognition [IDA]
- embryonic neurocranium morphogenesis [IMP]
- inner ear development [IMP]
- multicellular organismal development [TAS]
- neuromuscular process [IDA]
- optokinetic behavior [IDA]
- outer ear morphogenesis [IDA]
- regulation of behavior [IDA]
- semicircular canal formation [IMP]
- sensory perception of sound [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
SLIT2
SLIL3, Slit-2
slit homolog 2 (Drosophila)
GO Process (37)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- Roundabout signaling pathway [IC, IMP]
- apoptotic process involved in luteolysis [IEP]
- axon extension involved in axon guidance [IDA]
- axon guidance [IDA, TAS]
- branching morphogenesis of an epithelial tube [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to heparin [IDA]
- cellular response to hormone stimulus [IEP]
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration [IDA]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [IDA]
- corticospinal neuron axon guidance through spinal cord [IMP]
- induction of negative chemotaxis [IDA]
- motor neuron axon guidance [IDA]
- negative chemotaxis [IDA, IMP]
- negative regulation of actin filament polymerization [IDA]
- negative regulation of catalytic activity [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IDA, IMP]
- negative regulation of cellular response to growth factor stimulus [IDA]
- negative regulation of chemokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of lamellipodium assembly [IDA]
- negative regulation of leukocyte chemotaxis [IDA]
- negative regulation of monocyte chemotaxis [ISS]
- negative regulation of mononuclear cell migration [IDA]
- negative regulation of neutrophil chemotaxis [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of retinal ganglion cell axon guidance [IDA]
- negative regulation of small GTPase mediated signal transduction [IDA]
- negative regulation of smooth muscle cell chemotaxis [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of vascular permeability [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of axonogenesis [TAS]
- response to cortisol [IEP]
- retinal ganglion cell axon guidance [IDA]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID