BAIT
NLGN3
HNL3
neuroligin 3
GO Process (20)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- adult behavior [IMP]
- axon extension [ISS]
- learning [IMP]
- metabolic process [IBA]
- neuron cell-cell adhesion [IBA, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- receptor-mediated endocytosis [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISS]
- regulation of synaptic transmission [IBA, ISS]
- rhythmic synaptic transmission [ISS]
- social behavior [IMP]
- synapse assembly [IBA, ISS]
- synapse organization [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AES
AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5
amino-terminal enhancer of split
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- multicellular organismal development [TAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of response to cytokine stimulus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [TAS]
- positive regulation of anoikis [IMP]
- response to interleukin-1 [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID