BAIT
KIT
C-Kit, CD117, PBT, SCFR
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
GO Process (53)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- Fc receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- Kit signaling pathway [IDA]
- T cell differentiation [ISS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- cell chemotaxis [IDA]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell cytokine production [ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISS]
- digestive tract development [ISS]
- embryonic hemopoiesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- erythropoietin-mediated signaling pathway [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [TAS]
- immature B cell differentiation [ISS]
- inflammatory response [ISS]
- innate immune response [TAS]
- lamellipodium assembly [ISS]
- male gonad development [IEP]
- mast cell chemotaxis [IDA]
- mast cell cytokine production [IDA]
- mast cell degranulation [IMP]
- mast cell differentiation [ISS, TAS]
- mast cell proliferation [TAS]
- megakaryocyte development [ISS]
- melanocyte adhesion [ISS]
- melanocyte differentiation [ISS, TAS]
- melanocyte migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ovarian follicle development [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- pigmentation [ISS]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell proliferation [TAS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- spermatogenesis [ISS, TAS]
- stem cell differentiation [ISS]
- stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MPDZ
HYC2, MUPP1, RP11-382H24.1
multiple PDZ domain protein
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity.
We have identified the multiple PDZ domain containing protein (MUPP-1 or MPDZ) as a novel binding partner of the human c-Kit. c-Kit binds specifically to the 10th PDZ domain of MUPP-1 via its C-terminal sequence. Furthermore, a kinase negative-mutant receptor interacted more strongly with MUPP-1 than the wild-type c-Kit. Strikingly, a constitutively activated c-Kit (D816V-Kit) did not bind to MUPP-1, ... [more]
FEBS Lett. Sep. 29, 2000; 482(1);54-8 [Pubmed: 11018522]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIT MPDZ | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| MPDZ KIT | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID