SHANK3
Gene Ontology Biological Process
- MAPK cascade [ISS]
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- brain morphogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- guanylate kinase-associated protein clustering [ISS]
- learning [IMP, ISS]
- memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- negative regulation of cell volume [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of glutamate receptor signaling pathway [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of synapse structural plasticity [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density assembly [ISS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of long term synaptic depression [ISS]
- regulation of long-term synaptic potentiation [ISS]
- social behavior [IMP, ISS]
- striatal medium spiny neuron differentiation [ISS]
- synapse assembly [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PICK1
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- DNA methylation involved in embryo development [NAS]
- DNA methylation involved in gamete generation [TAS]
- cellular response to decreased oxygen levels [ISS]
- cellular response to glucose starvation [ISS]
- dendritic spine maintenance [ISS]
- dendritic spine organization [ISS]
- glial cell development [ISS]
- long term synaptic depression [ISS]
- monoamine transport [IDA]
- negative regulation of Arp2/3 complex-mediated actin nucleation [ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of receptor internalization [ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- protein phosphorylation [ISS]
- receptor clustering [ISS]
- retrograde vesicle-mediated transport, Golgi to ER [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
- ATPase activity [ISS]
- Arp2/3 complex binding [ISS]
- G-protein coupled receptor binding [ISS]
- actin filament binding [ISS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein domain specific binding [ISS]
- protein kinase C binding [ISS]
- receptor binding [ISS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHANK3 PICK1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID