BAIT
SHANK3
DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
SH3 and multiple ankyrin repeat domains 3
GO Process (27)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISS]
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- brain morphogenesis [ISS]
- dendritic spine morphogenesis [ISS]
- guanylate kinase-associated protein clustering [ISS]
- learning [IMP, ISS]
- memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- negative regulation of cell volume [ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of glutamate receptor signaling pathway [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of synapse structural plasticity [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density assembly [ISS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of long term synaptic depression [ISS]
- regulation of long-term synaptic potentiation [ISS]
- social behavior [IMP, ISS]
- striatal medium spiny neuron differentiation [ISS]
- synapse assembly [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VPS18
PEP3
vacuolar protein sorting 18 homolog (S. cerevisiae)
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID